Posts tagged ‘Pharma Market Research’
June 12th, 2013
At ASCO 2013, chronic lymphocytic leukemia (CLL), was probably one of the hottest topics at the conference after the anti PD-1/PD-L1 monoclonal antibodies.
CLL is a disease of the elderly, with an average age in the late 60′s to early 70′s range. For years, the mainstay of treatment has been chemo-immunotherapy with or without rituximab. People living with this indolent disease are prone to infections due to the immunosuppression that occurs over time. Fatigue and bulky adenopathy are also common as the disease progresses.
Over the last year or two, we’ve begun to see some exciting new possibilities emerge, with a number of new agents being evaluated in early phase clinical trials that target CD20, as well as the BTK and BCL2 pathways.
With several interesting new agents coming through the pipeline, Sally Church, PhD discussed the latest developments in CLL with Dr Susan O’Brien from MD Anderson. Recorded at ASCO 2013, the interview is part of the “Making a Difference” series published on Pharma Strategy Blog,
In her video interview, Dr O’Brien discusses several new agents – the first two already have Breakthrough therapy designation from the FDA:
- Obinutuzumab (GA101) – Roche/Genentech
- Ibrutinib – Pharmacyclics/J&J
- Idelalisib (CAL-101) – Gilead
- IPI-145 (INK128) – Infinity
- ABT-199 – AbbVie/Roche
You can read more about CLL on Pharma Strategy Blog, and in addition on Biotech Strategy Blog there is a pre-ASCO piece on the “CLL Runners and Riders in Race to Market.” For those interested in learning more about the CLL market, a report will be available over the summer.
May 28th, 2013
The annual meeting of the American Society of Clinical Oncology (twitter hashtag #ASCO13) is fast approaching. Later this week over 30,000 attendees will head to Chicago to hear the latest data on new cancer drugs and the results of clinical trials.
The expected highlight of the ASCO 2013 meeting will be data on PD-1 and PD-L1 immunotherapies: nivolumab (BMS), MPDL3280A (Roche) and lambrolizumab (Merck).
As Sally Church, PhD notes in her ASCO 2013 PD-1 PD-L1 highlights post on Pharma Strategy Blog when considering these new immunotherapies, important questions need to be answered:
- How much of a prolonged effect with PD-1/PD-L1 immunotherapies have over 5 years?
- What will be their effect on subsequent therapies?
- Will they boost or hinder sequencing and in which tumour types?
- Is there a biomarker of response?
- Is a diagnostic necessary?
Sally says “it continues to be an exciting area of oncology” and she’s “really looking to the presentations on PD-1/PD-L1.” We expect this to be the data of the meeting.
Another hot topic with a lot happening at ASCO 2013 is Chronic Lymphocytic Leukemia (CLL). Earlier this year the FDA granted it’s new Breakthrough designation to two drugs in development with CLL indications: ibrutinib from Pharmacyclics and obinutuzumab (GA101) from Roche/Genentech.
Other CLL new drugs with data at ASCO 2013 include idelalisib (GS-1101) from Gilead, IPI-145 from Infinity and ABT-199 being developed by Abbvie & Genentech. A cloud hangs over ABT-199 after the death of 2 CLL patients due to tumor lysis syndrome and this is likely to be a topic of discussion at ASCO. You can read more about the companies in the race to market in CLL on Biotech Strategy Blog.
Finally, you can now watch Sally Church’s video preview of what’s hot at ASCO 2013, it’s available for free, but you do have to sign-up on Pharma Strategy Reports to obtain the access link and password. Check it out!
May 21st, 2013
To celebrate the launch of Pharma Strategy Reports, we are offering a complimentary executive summary on Chimeric Antigen Receptor Technology (CART), written by Sally Church, PhD.
You can obtain your complimentary copy of this report on the Pharma Strategy Reports website. You will gain insights into:
- The challenges associated with immunotherapy and stimulating the immune system
- How are next generation immunotherapies making waves in cancer research?
- How recent papers in NEJM and Science & Translational Medicine have described this novel approach and what the preliminary data shows
- Some of the potential challenges or hurdles for registration of CTL019, the CART therapy being developed by Novartis.
CART is emerging as potential new exciting leukemia treatment – impressive results have been reported in a small cohort of adults with CLL and children with ALL who received the Novartis CTL019 therapy.
We expect there will be more data available at the 2013 annual meeting of the American Society of Hematology (ASH) later this year in New Orleans.
If you have an interest in understanding the potential of CART technology, then please sign up at Pharma Strategy Reports to download a complimentary executive summary. You will also be the first to know about future reports when they are published, such as what the new FDA Breakthrough designation means?
February 20th, 2013
Tumor Lysis Syndrome (TLS) has been in the news recently as a result of two patient deaths in a chronic lymphocytic leukemia (CLL) clinical trial with AbbVie’s ABT-199, a novel BCL-2 inhibitor in early stages of development.
What is TLS and why is this important in cancer research was subsequently analyzed by Icarus Consultants hematology industry expert, Sally Church, PhD on Pharma Strategy Blog.
Sally notes in her post, “we don’t yet know whether the effect in ABT-199 is a dose-schedule issue or a compound structure issue (especially given the reformulation from the original navitoclax issue).”
It’s a major setback to AbbVie ($ABBV) when the company was poised to start a phase 3 clinical trial with ABT-199 in CLL.
AbbVie will have to convince doctors that careful dose scheduling can solve the problem of a drug that may be too potent for the body to handle. Further deaths due to TLS could easily stop the development of this compound.
The setback to ABT-199 is, however, good news for ibrutinib that along with ABT-199 is in a race to market in CLL.
On February 12, 2013, ibrutinib received “breakthrough designation” from the FDA for the treatment of mantle cell lymphoma (MCL) and Waldenstrom’s macroglobulinemia.
Breakthrough designation means that a drug can be approved on the basis of early clinical data. Depending on when filing takes place, FDA approval of ibrutinib in MCL could be forthcoming later this year.
We expect to be producing a report on the CLL new products in development soon. This will cover some of the challenges and issues companies are facing. If you haven’t already done so, please sign up below if you would like to receive news alerts and be the first to know when reports are available.
February 18th, 2013
Celgene Corporation’s nab-paclitaxel (Abraxane) will be a new treatment for advanced pancreatic cancer. That was the news from the 2013 American Society of Clinical Oncology Gastrointestinal Cancers symposium (ASCO GI) that took place in San Francisco last month.
At the 2012 European Society of Medical Oncology (ESMO) meeting in Vienna, Sally Church, PhD noted on Pharma Strategy Blog that pancreatic cancer experts such as Margaret Tempero, MD were excited about the prospect of nab-paclitaxel in pancreatic cancer
The data presented at ASCO GI showed that for patients with metastatic adenocarcinoma of the pancreas, the addition of nab-paclitaxel to the chemotherapy gemcitabine led to an increase in median overall survival of 1.8 months compared to receiving gemcitabine alone (8.5 months versus 6.7 months, Hazard Ratio: 0.72, P=0.000015). While this may seem a small amount of time, there are few effective treatments for advanced pancreatic cancer.
By showing a significant increase in overall survival, Abraxane met the primary endpoint of the phase 3 MPACT clinical trial, and is likely to be approved by the FDA in the future.
Abraxane will provide a new treatment option in pancreatic cancer
The Abraxane data presented at ASCO GI was good, but it was not great. Sally Church interviewed Dr Hedy Lee Kindler, Associate Professor of Medicine at the University of Chicago about the significance of the data.
In her “Making a difference in Pancreatic Cancer Interview“, Dr Kindler says that for most of her patients she would still use FOLFIRINOX. This is a chemotherapy combination (5-fluorouracil, irinotecan, and oxaliplatin) that has side effects that need to be carefully managed.
It is only suitable for those patients who are well enough to take it, but offers a superior survival advantage in advanced pancreatic cancer. Data from the PRODIGE 4/ACCORD 11 study presented at the 2010 meeting of the American Society of Clinical Oncology (ASCO) showed the median overall survival time for patients receiving the FOLFIRINOX regimen to be 11.1 months.
Where we expect Abraxane to receive most pancreatic cancer use in the United States is from community oncologists who don’t wish to manage the side effects associated with FOLFIRINOX
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If you would like to learn more about the pancreatic cancer market and evolving treatment landscape, we will be publishing an in-depth report in the next few weeks.
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January 28th, 2013
Making sense of data is what we do. We live in a world where, thanks to the internet, the sheer volume of available data is increasing at an enormous rate.
Too often we see staff at client companies focus their energy on gathering data as cheaply as possible, instead of asking or seeking to understand what does all the data mean from a competitive stand point?
Data is now commoditized. Anyone can gain access to past ASCO Virtual Meetings, for example, and watch a rerun of conference presentations. While obtaining data is relatively easy, insights are a lot more expensive and difficult to generate.
Well, they require the application of knowledge, deep understanding and expertise of the topic to analyze, conceptualize and visualize data, and then extrapolate what it means to a company or product.
Here’s a fun video that shows how a picture tells a thousand words. Professor Hans Rosling, in this excerpt from a BBC documentary, shows the public health history of 200 countries in 4 minutes…
Turning data into a powerful illustration requires the expenditure of intellectual effort.
Making sense of data is what we do at Icarus Consultants.
October 29th, 2012
The 2012 Chemotherapy Foundation Symposium takes place at the Marriott Marquis in Times Square, New York City from November 7 – 10. Fortunately, the timing avoids the disruption expected this week from Hurricane Sandy.
The Greenspan Meeting as it’s also known (in recognition of the late Ezra M. Greenspan MD, the symposium founder) provides the opportunity for oncologists to learn about new developments in cancer therapy.
It is a joint presentation by the Mount Sinai School of Medicine and the non-profit Chemotherapy Foundation.
Sally Church, PhD who frequently attends says she particularly “enjoys the lectures that give a broad strategic overview of a particular topic.”
There’s usually a good turnout from the NJ/NY pharma industry and it’s interesting to talk to local academic and community oncologists about their practice.
You can read more about last year’s prostate cancer session at the 2011 Chemotherapy Foundation Symposium on Biotech Strategy Blog. The informative sessions cover a lot of ground and are well worth attending.
Update November 1, 2012 – Symposium not cancelled after Storm Sandy
Good to see The Chemotherapy Foundation announce on twitter today that the symposium will go on as scheduled. Hopefully the transport network will have some semblance of normality by then otherwise it will remain a challenge for many in the local area to attend.
The Chemotherapy Foundation Symposium will go on as scheduled. You can still register on chemotherapyfoundationsymposium.org
— Chemo Fdtn Symposium (@tcfsymposium) November 1, 2012
August 6th, 2012
When the dog days of summer and the Olympics are over, the normal rhythm of pharma marketing and new product development life continues with the major medical congresses and scientific meetings that take place in the Autumn/Fall.
A few of the meetings we will be attending and ones to watch out for include:
ESMO 2012 Congress, Vienna (#ESMO12) 28 September – 2 October, 2012
Building on the highly successful European Multidisciplinary Cancer Congress held in Stockholm last year, we expect the 2012 Congress of the European Society of Medical Oncology (ESMO) to be an exciting meeting.
ESMO have already announced that abstract submissions are up 30%. We expect a lot of interesting new data to be presented in Vienna, especially in light of the fact that the deadline for presentation at ASCO in June was very early this year. If you are interested in attending, the late registration deadline is August 22nd.
NYAS Pancreatic Cancer: Translation of New Ideas, New York, 12 October, 2012
For those interested in pancreatic cancer and insights into some of the preclinical and translational research that is being done with targeted drugs, a half-day meeting at The New York Academy of Sciences (NYAS) looks worth attending.
The keynote speaker is Dafna Bar-Sagi, PhD, Professor and Vice Dean for Science at the NYU Langone Medical Center. Icarus Consultants is pleased to be a promotional partner for the event. The inexpensive registration fee for nonmembers is only $40, with a networking reception to follow.
EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin 6 – 9 November, 2012
Hosted by the European Organization for Research and Treatment (EORTC), National Cancer Institute (NCI) and American Association for Cancer Research (AACR), this symposium is one of Sally Church’s favorite meetings of the year, with its focus on innovation in drug development, target selection and new products.
We hope to see you in Vienna, New York or Dublin!
June 29th, 2012
The Supreme Court decision upholding the Affordable Care Act (ACA) means that the sun did not set on the provisions of the Physician Payment Sunshine Act that were contained within it.
Manufacturers of pharmaceuticals and medical devices will be required to report all payments and transfers of value (e.g. honoraria, consulting fees, travel expenses, meals) made to physicians and teaching hospitals.
The good news for Pharma market research vendors is that anonymous market research, where the sponsoring company does not know the names of the doctors interviewed, does not have to be reported.
Market research is not referred to directly in section 6002 of the ACA, but the “exemption” can be inferred from the definition of “payment or other transfer of value” in the Act:
Such term does not include a transfer of anything of value that is made indirectly to a covered recipient through a third party in connection with an activity or service in the case where the applicable manufacturer is unaware of the identity of the covered recipient.
This makes a lot of sense, after all, how can you potentially influence prescribing if you don’t know who is being paid by your market research vendor.
March 10th, 2012
One of the emerging trends we saw at the recent European Association of Urology (EAU) Congress in Paris was an increase in the number of plenary and session presentations by physicians from Eastern European countries.
This trend is set to continue, and we expect to see more physicians from the BRIC (Brazil, Russia, India & China) group of countries and other emerging markets presenting at global science and medical meetings in the future.
Poland is a good example of a country that should be on the radar of any global pharmaceutical company. It is one of the fastest growing economies in Europe, and was the only European country to avoid a recession in 2008-2009.
It was interesting to note that Tomasz Borkowski (Department of Urology at the Medical University of Warsaw) who gave a major session presentation at EAU on “Cancer induced bone disease – prevention and treatment’ listed only one company on his disclosures.
Clearly, some companies are ahead of others in identifying and building relationships with thought or key opinion leaders (KOLs) as they are commonly known.
One of the services we offer clients is market research with thought leaders at the global, national and regional level. Like all market research, this is anonymous – you don’t know the name or the institution and the physician doesn’t know who the sponsor is. This allows the doctor to speak more freely. This type of market research can provide valuable insights into what they think about a product or market opportunity with less bias.
Do you know who your thought leaders are and what think about your product? If not, please contact us and we would be delighted to help you meet your brand business goals.