Posts tagged ‘mTOR signaling pathway’
December 18th, 2011
Updated results from the BOLERO-2 (breast cancer trials of oral everolimus) were presented at the recent San Antonio Breast Cancer Symposium (SABCS).
José Baselga had previously presented the impressive results at ECCO/ESMO 2011 in Stockholm.
As Sally Church noted on Pharma Strategy Blog in her second update on “what’s hot at SABCS”:
“The trial data presented by Dr Gabriel Hortobagyi (MDACC) confirmed that the responses continue to be durable, with an improvement in PFS with the combination arm now up to 11.0 months, up from 10.6 months at ECCO. The results for the exemestane control arm remained at 4.1 months.”
The extra 6.9 months of survival benefit shown with exemestane plus the mTOR inhibitor everolimus is good news for advanced breast cancer patients.
One of the problems associated with aromatase inhibitor (AI) therapy in breast cancer is that patients develop resistance over time. As Sally notes,
“The rationale behind this trial is that mTOR is a known cause of resistance to AI therapy, so the combination targets both the estrogen receptor and mTOR adaptive resistance pathway.”
You can read more on Pharma Strategy Blog about the BOLERO-2 trial presented at the San Antonio Breast Cancer Symposium and why this was a rationally designed study based on solid science.