Posts tagged ‘melanoma market research’
August 25th, 2011
Last week the hot news was the anticipated FDA approval of vemurafenib (Zelboraf™) in metastatic melanoma for patients with BRAF V600E mutations.
“the good news is that oncologists now have two new agents for treatment in 2011, which is very much a grand cru year for melanoma.”
A little known fact is that Sally is a former finalist in the UK Daily Telegraph newspaper’s wine taster of the year competition, so it is perhaps not surprising to see some wine references in her writing.
If you are interested in the price of Zelboraf™ – you can find it on Pharma Strategy Blog where Sally analyses the cost of a course of treatment and compares this to the price for ipilimumab.
Pieter Droppert’s write-up of the 2011 ASCO annual meeting plenary data on metastatic melanoma was recently published in the august issue of Pharmacy Today.
April 25th, 2011
Targeted therapies for metastatic melanoma such as PLX4032 (vemurafenib) have shown dramatic effects in patients. However, resistance to BRAF inhibitors such as PLX4032 soon develops. The result is a need to understand how resistance occurs due to cross talk and how to overcome this through a rational drug combination strategy.
Sally Church on Pharma Strategy Blog delves into the topic of BRAF resistance with demonstrable enthusiasm. In her insightful post she discusses data presented in the plenary session at the recent annual meeting of the American Association for Cancer Research (AACR) by Levi Garraway from Dana Farber.
As Sally discusses in some detail, the research identified a novel mutation in the downstream kinase MEK1 that may be the reason why patients become resistant to PLX4032.
April 20th, 2011
At the recent Association of Health Care Journalists (AHCJ) annual meeting in Philadelphia that Pieter Droppert attended, one of the keynote speakers was Francis Collins, Director of the National Institutes of Health (NIH).
In his presentation he drew the attention of the assembled audience to exciting new research supported by the NIH on whole-exome sequencing of melanoma.
This research published recently in Nature Genetics has led to the discovery of the GRIN2A mutation and further insight into the association between the glutamate pathway and melanoma. GRIN2A mutations were found in 33% of NIH/NCI sample set.
Glutamate antagonists limit tumor growth and may be a new druggable target in melanoma.
Sally Church has written extensively about melanoma. In a post on Pharma Strategy Blog, Sally looks in more detail at the discovery of the GRIN2A mutation and what this means for melanoma new product development. You can read more here.