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Understanding why melanoma patients develop resistance to PLX4032

Targeted therapies for metastatic melanoma such as PLX4032 (vemurafenib) have shown dramatic effects in patients. ¬†However, resistance to BRAF inhibitors such as PLX4032 soon develops. The result is a need to understand how resistance occurs due to cross talk and how to overcome this through a rational drug combination strategy. Sally Church on Pharma Strategy […]

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