Posts tagged ‘BPX-101’
The fast moving prostate cancer market took another leap forward last week with the announcement of positive phase III data for Medivation’s MDV3100.
As reported by Sally Church on Pharma Strategy Blog, Medivation announced that the interim analysis of the AFFIRM trial showed a 4.8 month increase in overall survival (OS) compared to placebo.
Although this is only interim and not final data, Sally observed:
“the 4.8 month improvement in OS in post-chemo setting is superior to that previously seen reported for abiraterone (Zytiga), which had a 3.9 month advantage over placebo.”
Pieter Droppert on Biotech Strategy Blog noted, MDV3100 and Zytiga have completely different mechanisms of action in advanced prostate cancer.
MDV3100 is an androgen receptor blocker, while Zytiga is an androgen biosynthesis inhibitor. This distinction is key. Zytiga inhibits the CYP17 enzyzme complex required for androgen biosynthesis. However, a consequence of CYP17 inhibition is an increase in mineralocorticoid levels, which can lead to hypokalemia, hypertension, fluid retention.
The result is that Zytiga requires coadministration of a corticosteroid (prednisone) to reduce the incidence and severity of potential mineralocorticoid adverse reactions.
MDV3100 does not require the administration of a steroid, which is a big advantage to patients. Instead it blocks the androgen receptor (AR) that is highly expressed on prostate cancer cells.
Cora Sternberg presents Prostate Cancer Educational Symposia at EMCC 2011 in Stockholm
There are a lot of new products in the pipeline for prostate cancer including TAK-700, Cabozantinib (XL184), radium-223 chloride (Alpharadin), BPX-101, Prostvac-VF, ipilumumab, Custirsen (OGX-011), dasatinib (Sprycel), lenalidomide (Revlimid) and ARN-509 to name a few.
The prostate cancer market is forecast to grow from $1B to $5B by 2015 as new products are approved and new treatment options become available. This is good news for advanced prostate cancer patients.
The 2011 annual meeting of the American Urological Association (AUA) ended in Washington DC today.
Some of the highlights of the meeting were written about on Pharma Strategy Blog and Biotech Strategy Blog, these include:
PIVOT (Prostate Cancer Intervention versus Observation Study)
The data from this study was presented in Tuesday’s plenary session by Dr Tim Wilt, a Professor at the University of Minnesota, and was to many attendees, the highlight of the meeting.
The trial results showed for the first time that radical prostatectomy (RP) is no better than watchful waiting in men with early stage prostate cancer using evidence based medicine.
This groundbreaking research is likely to have a major impact on urology practice in the United States.
Pieter Droppert wrote about the PIVOT results on Biotech Strategy Blog. Scott Hensley on NPR’s Health Blog, “Shots” references Pieter’s post, and has an interview with Dr Wilt that is also well worth reading.
Also presented at AUA in Tuesday’s plenary session were the results from:
Denosumab (Xgeva®) 147 phase III trial
This study looked at castrate resistant prostate cancer patients at high risk of development of bone metastasis.
Sally Church on Pharma Strategy Blog discusses the results presented by Dr Matthew Smith at AUA. Denosumab was shown to increase bone metastasis-free survival and delayed time to first bone metastasis, but did not increase overall survival (OS).
Both Sally Church and Pieter Droppert also wrote additional blog posts from the meeting. On Biotech Strategy Blog, Pieter wrote about data that showed:
He also wrote about:
New Prostate Cancer products in development beyond the androgen axis
Some of the new products mentioned in Pieter’s post include alpharadin, XL-184 (cabozantinib), Prostvac-VF, BPX-101 and ipilimumab. You can read more on Biotech Strategy Blog.
Meanwhile on Pharma Strategy Blog, Sally Church continued one of her themes of how social media is impacting medical conferences by reviewing:
How AUA have embraced Social Media in 2011
Sally also recorded a video blog post (vlog) from AUA that highlighted some of the exciting developments in basic biology and how this may lead to new Prostate Cancer treatments in the future. Click here to watch this.
If you were unable to attend the meeting, Sally aggregated the #AUA2011 tweets.
Selecting what to write about on a blog is subjective, so the above posts are not intended to provide comprehensive meeting or conference coverage, only a few highlights of what was presented at the highly informative and educational AUA annual meeting.
If you are interested in a more comprehensive report on the Prostate Cancer Market and the emerging new products in development, please do not hesitate to contact us.