Published by Sally Church on Pharma Strategy Blog
Smads have been cropping up in GI sessions at meetings over the last six months or so. Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily, so they occupy a key role in transcription of proteins.
Essentially, the translational research from Soond and Chantry (2011) is suggesting that blocking the WWP2 gene could prevent metastasis, ie cancers from spreading to other organs of the body.
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