Aß40 Oligomers are a potential biomarker for diagnosis of Alzheimer’s before amyloid plaque develops

A recent paper published in PLoS One (open access) describes how Aß40 Oligomers have potential as a biomarker for Alzheimer’s disease (AD), prior to the development of amyloid plaque.

In their paper, Gao et al describe how using the knowledge that soluble Aß oligomers play an important role in the pathogenesis of AD, they were able to use a Misfolded Protein Assay (MPA) to capture Aß in the cerebrospinal fluid (CSF) of AD patients.  Their results suggest that Aß40 oligomers are a novel biomarker for the early diagnosis of AD.

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